Indeed, when tricyclic antidepressants TCAs were the main treatment option, these relatively narrow TI drugs could be used by the patient to end their lives.
The therapeutic window Figure 1. The awkward case of 'his or her'. Conjugating an irregular verb.
Explore the year a word first appeared. Essentially, all drug treatment is really a compromise between positive and negative effects in the patient.
Fortunately, more modern drugs such as the SSRIs selective serotonin reuptake inhibitors have much higher TIs, so the risk of the patient using the drugs for a suicide attempt is greatly diminished. Over the last 30 years, the drug industry has aimed to replace this type of drug with agents with much higher TIs.
Such is human variation that our personal therapeutic windows are effectively unique for every drug we take. This effectively means the most beneficial pharmacodynamic effects for the minimum side effects. The patient may continue to take the drug at the correct dosage, but drug levels may drop out of, or exceed, the therapeutic window.
Resources for therapeutic window Time Traveler! Drugs vary enormously in their toxicity and the concentrations at which one drug might cause potentially lethal effects might be 10 or 100 times lower than a much less toxic drug.
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Comments on therapeutic window What made you want to look up therapeutic window? So, theoretically, the drug should remain in its therapeutic window for as long as therapy is necessary unless other factors change this situation.
Next post: Play the game. Test Your Knowledge - and learn some interesting things along the way. Facebook Twitter YouTube Instagram.Video Explanation 1: Dose Response and Therapeutic Index