Ankyrin repeat and SOCS box protein 15 regulates protein synthesis in skeletal muscle. Cowper-Sal lari, R.Epigenetic regulation in stem cells and reprogramming
Cancer 42 , 1661—1670 2006. This study made use of genotyping data on the 1958 Birth Cohort generated by the Wellcome Trust Sanger Institute http: The adequacy of the case—control matching and possibility of differential genotyping of cases and controls was evaluated using a Q—Q plot of test statistics Supplementary Fig.
Thus far, there has only been limited evaluation of this possibility with no evidence for significant differences 44. Genome-wide association studies GWAS have transformed our understanding of susceptibility to multiple myeloma MM , but much of the heritability remains unexplained.
Kile, B. Cancer Epidemiol.
To estimate the sample size required to explain a greater proportion of the GWAS heritability, we implemented a likelihood-based approach using association statistics in combination with LD information to model the effect-size distribution 15 , 16. Familial risks and temporal incidence trends of multiple myeloma.
Controls were also genotyped using the OncoArray and comprised: Fluorescence in situ hybridisation FISH and ploidy classification of UK and German samples were performed as previously described 53 , 54.
Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism.
Aside from previously reported relationships between the risk loci at 11q13. The 1000 genomes project: Competing mechanisms for the same gene e.
Association statistics were calculated for all SNPs conditioning on the top SNP in each loci showing genome-wide significance. It is noteworthy that the promising risk locus at 6p25.
After meta-analysis of the new and pre-existing GWAS data sets and replication series, we identified genome-wide significant associations i. This was carried out step-wise. Cairns, J. Gregory in: Davies in: