Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development  "After acquiring competence for selected cell fates, embryonic primordia may remain plastic for variable periods before tissue identity is irrevocably determined commitment.
The study of organogenesis is important not only because of its relevance to understanding fundamental mechanisms of animal development, but also because it may lead to medical applications , such as the repair and replacement of tissues affected by genetic disorders, disease or injury. Together, these studies indicate how multiple growth factors and signaling pathways can cooperate in preimplantation development.
From these studies emerged the theory that maternal signals, or developmental effects that the mother contributes to the egg prior to fertilization , act through three main families of protein-coding genes to help regulate the early differentiation of endoderm.
In the mouse, LR symmetry is broken at a midline structure, the node, and involves signal relay to the lateral plate, where it results in asymmetric organ morphogenesis.
Nieuwkoop, at the Hubrecht Laboratory in the Royal Netherlands Academy of Arts and Science, in Utrecht, Holland, discovered that endoderm induces adjacent ectoderm to form mesoderm.
Both layers contain muscle fibres and a two-dimensional web of nerve…. View More.
This stalk will later degenerate and all connection will normally be lost. But when he recombined the two tissues, the endoderm induced the formation of mesoderm in adjacent regions of the ectoderm. Pander, Christian. The yolk sac is pushed to the periphery by the growing amniotic sac, with its connecting yolk stalk in the umbilicus region.
Both epidermis and neural plate are capable of giving rise to neural crest cells.
In 1825, eight years after Pander's initial descriptions, Martin Rathke, a physician and embryologist from Prussia now Poland , discovered layers of cells in a developing invertebrate crayfish , Astacus astacus , that corresponded to those Pander had described in chicks. Huxley, Thomas Henry. The Rattlesnake voyage. Heft I. Pander's description of the formation of these layers is the first account of gastrulation in the chick , and it grounded future studies of the germ layers.
Cite this page: Vertebrate endoderm development. Induction by the Endoderm. Endoderm is one of the germ layers—aggregates of cells that organize early during embryonic life and from which all organs and tissues develop. Nieuwkoop, Pieter D.